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Indications - Sucralfate is indicated in adults and adolescents over 14 years old for treatment of- Duodenal ulcer Gastric ulcer Chronic gastritis The prophylaxis of gastrointestinal hemorrhage from stress ulceration in seriously ill patients.

Dosage & Administration - Dosage Duodenal ulcer, gastric ulcer, chronic gastritis- Adults: The usual dose is Sucralfate 2 gm twice daily to be taken on rising and at bedtime or Sucralfate 1 gm four times a day to be taken 1 hour before meals and at bedtime. Maximum daily dose is 8 gm but up to twelve weeks may be necessary in resistant cases. Pediatric population: The safety and efficacy of Sucralfate in children under 14 years of age has not been established. Elderly: There are no special dosage requirements for elderly patients but as with all medicines the lowest effective dose should be used. Prophylaxis of gastrointestinal hemorrhage from stress ulceration- Adults: The usual dose is Sucralfate 1 gm orally or via a nasogastric tube 4 to 6 times a day. To prevent clogging of the nasogastric tube flush with 10 ml of water following each administration. The duration of treatment for prophylaxis of stress ulceration must be individually determined. Treatment should be continued for as long as one or more of the risk factors for stress ulceration is present but normally not for more than 14 days. Administration Sucralfate should be taken on an empty stomach. Antacid should not be administered within 30 minutes of Sucralfate.

Side Effects - The most common adverse event was headache (3.4%) followed by nausea (2.3%), abdominal pain (2.3%), constipation (1.1%), diarrhea (1.1%), and urticaria (1.1%). The majority of patients who reported bezoars, had underlying medical conditions that may predispose to bezoar formation (such as delayed gastric emptying) or were receiving concomitant enteral tube feedings. Episodes of hyperglycemia have been reported in diabetic patient.

Contraindications - Sucralfate tablet and suspension are contraindicated in patients with hypersensitivity to sucralfate.

Others - Pregnancy & Lactation Safety in pregnant women has not been established and Sucralfate should be used during pregnancy only if clearly needed. It is not known whether this drug is excreted in human milk. Caution should be exercised when Sucralfate is administered to breast-feeding women.