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Indications - Alendronic Acid & Vitamin D3 is indicated in: Treatment of osteoporosis in postmenopausal women. Treatment of osteoporosis in men. Treatment of osteoporosis as it increases the bone mass and reduces the incidence of fractures, including those of the hip and spine.

Dosage & Administration - Dosage Treatment of Osteoporosis in Postmenopausal Women: The recommended dosage is- 70 mg alendronate and 2800 IU vitamin D3 or 70 mg alendronate and 5600 IU vitamin D3 tablet once weekly. For most osteoporotic women, the appropriate dose is 70 mg alendronate and 5600 IU vitamin D3 once weekly. Treatment to Increase Bone Mass in Men with Osteoporosis: The recommended dosage is- 70 mg alendronate and 2800 IU vitamin D3 or 70 mg alendronate and 5600 IU D3 tablet once weekly. For most osteoporotic men, the appropriate dose is 70 mg alendronate and 5600 IU vitamin D3 once weekly. Administration To permit adequate absorption, Alendronate & Colecalciferol must be taken at least 30 minutes before the first food, beverage or medication of the day with plain water only. Other beverages (including mineral water), food and some medications are likely to reduce the absorption of Alendronate. To facilitate delivery to the stomach and thus to reduce the potential for esophageal irritation, Alendronate & Colecalciferol tablet should only be swallowed upon rising for the day with a full glass of water. Patients should not lie down for at least 30 minutes after taking Alendronate until after their first food of the day. Alendronate & Colecalciferol should not be taken at bed time.

Side Effects - Usually mild and generally do not require discontinuation of therapy. Side effects include esophageal reactions, abdominal pain and distension, diarrhoea or constipation, flatulence, musculoskeletal pain, headache, rash, erythema and transient decreases in serum calcium and phosphate.

Contraindications - Abnormalities of the esophagus which delay esophageal emptying, such as stricture or achalasia. Inability to stand or sit upright for at least 30 minutes. Hypersensitivity to any component of this product. Hypocalcaemia.

Others - Pregnancy & Lactation Pregnancy category C. Overdoses of vitamin D have shown teratogenic effects in pregnant animals. Alendronic Acid & Vitamin D3 (Colecalciferol) should be used during pregnancy only if the potential benefit justifies the potential risk to the mother and fetus. Cholecalciferol and some of its active metabolites pass into breast milk. It is not known whether alendronate is excreted in human milk. Caution should be exercised when administered to lactating women.