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Indications - Ciprofloxacin is indicated for the treatment of Respiratory Tract Infections,Urinary tract infections, Pelvic Inflammatory Diseases, Infectious Diarrhea (Shigella dysenteriae, Vibrio cholera), Typhoid fever, Intra-abdominal infections, Prostatitis, Skin and Soft Tissue Infections, Bone and Joint Infections, Gonorrhea, Neutropenic patients with fever due to bacterial infection, Meningitis, Surgical prophylaxis.

Dosage & Administration - Dosage Tablet: Adult: Respiratory Tract Infections: 500 to 750 mg twice daily (7 to 14 days) Urinary tract infections: 250 to 750 mg twice daily (3 to 10 days) Pelvic Inflammatory Diseases: 500 to 750 mg twice daily (14 days) Infectious Diarrhea (Shigella dysenteriae, Vibrio cholera): 500 mg twice daily (1 to 5 days) Typhoid fever: 500 mg twice daily (7 days) Intra-abdominal infections: 500 to 750 mg twice daily (5 to 14 days) Prostatitis: 500 to 750 mg twice daily (2 to 6 weeks) Skin and Soft Tissue Infections: 500 to 750 mg twice daily (7 to 14 days) Bone and Joint Infections: 500 to 750 mg twice daily (max. 3 months) Gonorrhea: 500 mg as a single dose Neutropenic patients with fever due to bacterial infection: 500 to 750 mg twice daily co-administered with appropriate antibacterials. Meningitis: 500 mg as a single dose. Surgical prophylaxis: 500 mg as a single dose, 60 minutes before the procedure. Suspension: Pediatric: 10-20 mg/kg (max. 750 mg) twice daily (10 to 21 days). The duration of therapy depends on the type and severity of the infection. Extended-release tablet: In uncomplicated urinary tract infection (acute cystitis), the recommended dose of extended-release tablet is 1000 mg tablet once daily for three days. For IV infusion: Urinary Tract Infection: Mild to Moderate: 200 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 12 hourly for 7-14 days Lower Respiratory Tract infection: Mild to Moderate: 400 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14 days Nosocomial Pneumonia: Mild/Moderate/Severe: 400 mg 8 hourly for 10-14 days Skin and Skin Structure: Mild to Moderate: 400 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14 days Bone and Joint Infection: Mild to Moderate: 400 mg 12 hourly for more than 4-6 weeks; Severe/Complicated: 400 mg 8 hourly for more than 4-6weeks Intraabdominal (Acute abdomen): Complicated: 400 mg 12 hourly for 7-14 days Acute Sinusitis: Mild/Moderate: 400 mg 12 hourly for 10 days Chronic Bacterial Prostatitis: Mild/Moderate: 400 mg 12 hourly for 28 Days. Administration Instruction for the use of Ciprofloxacin IV infusion- Check the bag for minute leaks by squeezing the inner bag firmly. If leaks are found, or if seal is not intact, discard the solution. Do not use if the solution is cloudy or a precipitate is present. Do not use flexible bags in series connections. Close flow control clamp of administration set. Remove cover from port at bottom of bag. Insert piercing pin of administration set into port with a twisting motion until the pin is firmly seated. Suspend bag from hanger. Squeeze and release drip chamber to establish proper fluid level in chamber during infusion of Ciprofloxacin IV infusion. Open flow control clamp to expel air from set.Close clamp. Regulate rate of administration with flow control clamp Duration of treatment: The duration of treatment depends upon the severity of infection, clinical response and bacteriological findings. For acute infections the usual treatment period is 5 to 10 days. Generally treatment should be continued for 3 days after the signs and symptoms of the infection have been disappeared.

Side Effects - Side effects include- nausea and other gastrointestinal disturbances, headache, dizziness, joint pain and skin rashes.

Contraindications - It is contraindicated in patients who have known hypersensitivity to Ciprofloxacin or other quinolones.

Others - Pregnancy & Lactation There are no adequate and well-controlled studies in pregnant women. Ciprofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus and mother. Ciprofloxacin is excreted in human milk. Due to the potential risk of articular damage, Ciprofloxacin should not be used during lactation. Precautions & Warnings Patients receiving Ciprofloxacin should be instructed to drink fluids liberally. It should be used with caution in patients with suspected or known CNS disorders such as epilepsy or other factors which predispose to seizures and convulsion. Avoid in patients with known QT prolongation, hypokalemia. Use in Special Populations Although effective in clinical trials, Ciprofloxacin is not a drug of first choice in pediatric population. Overdose Effects Overdose following Ciprofloxacin administration may lead to seizures, hallucinations, confusion, abdominal discomfort, renal and hepatic impairment as well as crystalluria, haematuria, & reversible renal toxicity. Storage Conditions Keep below 30°C temperature, protected from light & moisture. Keep out of the reach of children.