Indications - This is indicated in- Patients with essential hypertension Patients with angina pectoris & hypertension as co-existing diseases ln post Ml patients ln patients with refractory angina pectoris where nitrate therapy has failed.
Dosage & Administration - Adult: This therapy is initiated with a single dose of this preparation depending upon the therapeutic response, titration of the dosage is recommended. In elderly patients: It is advisable to initiate the therapy with ½ tablet of fixed dose combination of Amlodipine & Atenolol, i.e., 2.5 mg of Amlodipine & 25 mg Atenolol.
Side Effects - The combination of Amlodipine and Atenolol is well tolerated. Overall side-effects include fatigue, headache, edema, nausea, drowsiness, anxiety and depression.
Contraindications - Hypersensitivity to either component, sinus bradycardia, second and higher degrees of heart block, cardiogenic shock, hypotension, congestive heart failure, poor left ventricular function.
Others - Pregnancy & Lactation The combination should be used during pregnancy only if the expected benefit outweighs the potential fetal risk. The combination should not be used by nursing mothers. If its use is considered necessary, breast-feeding should be stopped. Overdose Effects Though not documented, hypotension and less frequently congestive cardiac failure may occur in cases of overdosage. Unabsorbed drugs may be removed by gastric lavage or administration of activated charcoal. Symptomatic treatment is suggested.