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Indications - Propantheline Bromide is indicated in the treatment of- Adjunctive therapy in the treatment of peptic ulcer (gastric and duodenal) Relief of the symptoms of gastritis (stomach upset, gastrointestinal bleeding, blood in vomit, blood in stool, persistent pain) Symptomatic treatment of the diarrhoea related irritable bowel syndrome (irritable colon, spastic colon, acute enterocolitis, functional Gl disorders etc) Urinary incontinence Control of salivation and enuresis Improves lactose intolerance Prevents excessive sweating (Hyperhidrosis)

Dosage & Administration - The usual initial adult dose of Propantheline Bromide is 75 mg daily. One tablet 30 min before each meal (15 mg three times daily). Two tablets at bedtime Dosage adjustment should be made according to the patient's individual response and tolerance. But the maximum daily dosage should not exceed 120 mg. Pediatric use: Safety and effectiveness in pediatric patients have not been established.

Side Effects - The adverse effects of Propantheline Bromide are usually dose-related and are usually reversible when the therapy is discontinued. Variable degrees of dry mouth, dry skin, mydriasis might be noted. Other reported adverse effects include urinary retention, nausea, vomiting, constipation, headache, nervousness, mental confusion etc.

Contraindications - Propantheline Bromide is contraindicated in patients with- Hypersensitivity to Propantheline bromide or other anticholinergic agents; Glaucoma; Obstructive disease of the gastrointestinal tract (pyloroduodenal stenosis, paralytic ileus etc.); Obstructive uropathy (e.g. prostatic hypertrophy) intestinal atony of elderly; Myasthenia gravis.

Others - Pregnancy & Lactation Propantheline Bromide is in pregnancy category C. Animal reproduction studies have not been conducted with propantheline bromide. Propantheline bromide should be given to a pregnant woman only if clearly needed. It is not known whether this drug is excreted in milk. Because many drugs are excreted in milk, caution should be exercised when propantheline bromide is administered to a nursing woman. Suppression of lactation may occur with anticholinergic drugs.