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Indications - Sertraline is indicated for the treatment of- Major depressive disorder (MDD) Obsessive-compulsive disorder (OCD) Panic disorder (PD) Post-traumatic stress disorder (PTSD) Social anxiety disorder (SAD) Premenstrual dysphoric disorder (PMDD).

Dosage & Administration - Adults- Major depressive disorder: Starting Dose: 50 mg Therapeutic Range: 50-200 mg Obsessive-compulsive disorder: Starting Dose: 50 mg Therapeutic Range: 50-200 mg Panic disorder, Post-traumatic stress disorder, Social anxiety disorder: Starting Dose: 25 mg Therapeutic Range: 50-200 mg Pediatric Patients (ages 6-12 years old)- Obsessive-compulsive disorder: Starting Dose: 25 mg Therapeutic Range: 50-200 mg The recommended interval between dose changes is one week. Premenstrual dysphoric disorder (PMDD): Starting dosage for PMDD is 50 mg/day. Sertraline may be administered either continuously (every day throughout the menstrual cycle) or intermittently (starting the daily dosage 14 days prior to the anticipated onset of menstruation and continuing through the onset of menses). Intermittent dosing would be repeated with each new cycle. Continuous: Patients not responding to a 50 mg dosage may benefit from dosage increases at 50 mg increments per menstrual cycle up to 150 mg per day. Intermittent: Patients not responding to a 50 mg dosage may benefit from increasing the dosage up to a maximum of 100 mg per day during the next menstrual cycle (and subsequent cycles).

Side Effects - Sertraline may cause side effects like upset stomach, diarrhoea, constipation, vomiting, dry mouth, loss of appetite, weight changes, drowsiness, dizziness, headache, pain, burning or tingling in the hands or feet, excitement, sore throat etc.

Contraindications - Sertraline is contraindicated in patients with a known hypersensitivity to Sertraline or any of the excipients of drug. In patients with moderate to severe hepatic impairment is not recommended.

Others - Pregnancy & Lactation Although animal studies did not provide any evidence of teratogenicity, the safety of Sertraline during human pregnancy has not been established. Sertraline is known to be excreted in breast milk. Its effects on the nursing infant have not yet been established. If treatment with Sertraline is considered necessary, discontinuation of breast-feeding should be considered.