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Indications - Naftidrofuryl oxalate is used to treat peripheral vascular disorders (blood circulation problems outside the brain and heart). It is used to treat the following symptoms of these disorders:  Intermittent claudication  Cramps in legs at night  Severe pain in legs while resting (rest pain)  Pale or blue fngers or toes which get worse when it is cold  Numbness, tingling or burning feelings in fngers or toes (Raynaud’s syndrome or acrocyanosis)  Open sores on the legs or feet (trophic ulcers)  Poor circulation caused by diabetes (diabetic arteriopathy)  To treat gangrene

Dosage & Administration - One or two Naftidrofuryl oxalate capsules three times daily during meals for a minimum of three months or at the discretion of the physician

Side Effects -  Gastrointestinal disorders (uncommon): Diarrhoea, nausea, vomiting and epigastric pain.  Renal and urinary disorders (very rare): Calcium oxalate kidney stones.  Skin and subcutaneous tissue disorders (uncommon): Skin rash.  Hepatobiliary disorders (rare): Liver damage.

Contraindications - Hypersensitivity to the active substance or to any of the excipients. Patients with a history of hyperoxaluria or recurrent calcium-containing kidney stones.

Others - Pregnancy & Lactation In the absence of any relevant clinical data, the use of Naftidrofuryl Oxalate is not advisable during pregnancy. In the absence of specific data concerning the excretion of the drug in human milk, Naftidrofuryl Oxalate should not be used by breastfeeding women.