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Indications - Flunarizine is indicated for Prophylaxis of classic (with aura) or common (without aura) migraine Symptomatic treatment of vestibular vertigo (due to a diagnosed functional disorder of the vestibular system). Peripheral Vascular Disease (PVD) Motion sickness Refractory epilepsy resistant to conventional antiepileptic therapy

Dosage & Administration - Migraine Prophylaxis: Starting Dose: 10 mg at night in patients less than 65 years of age and 5 mg daily in patients older than 65 years. If, during this treatment depressive, extrapyramidal or other unacceptable symptoms occur, administration should be discontinued. If, after 2 months of this initial treatment, no significant improvement is observed, the patient should be considered a non-responder and administration should be discontinued. Maintenance Treatment: If a patient is responding satisfactorily and if a maintenance treatment is needed, the dose should be decreased to 5 days treatment at the same daily dose with two successive medicine free days every week. Even if the prophylactic maintenance treatment is successful and well tolerated, it should be interrupted after 6 months and it should be re-initiated only if the patient relapses. Peripheral Vascular disease: 10 mg twice daily, up to 30 mg per day if required. Vertigo & motion sickness: 10-20 mg daily for adults and 5 mg daily for children (> 40 kg). Epileptic seizure: 15-20 mg daily in adults and 5 to 10 mg daily for children as an add-on therapy

Side Effects - Drowsiness and/or fatigue, as well as weight gain and/or increased appetite may occur. The following adverse experiences have been reported during chronic treatment with Flunarizine: depression, of which female patients with a history of depressive illness may be particularly at risk; extrapyramidal symptoms (such as bradykinesia, rigidity, akathisia, orofacial dyskinesia, tremor), of which elderly patients seem particularly at risk. Infrequently reported adverse reaction are: heartburn; nausea; gastralgia; insomnia; anxiety; galactorrhoea; dry mouth; muscle ache; skin rash.

Contraindications - Hypersensitivity to Flunarizine. Flunarizine is contra-indicated in patients with a history of depressive illness, or with pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders.

Others - Pregnancy & Lactation Safety in pregnancy and lactation has not been established.