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Indications - Cefpodoxime is indicated for the treatment of infections caused by susceptible microorganism, listed below: Acute otitis media caused by Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenza, Moraxella catarrhalis (including beta-lactamase producing strains). Pharyngitis/tonsillitis caused by Streptococcus pyogenes. Acute maxillary sinusitis caused by Haemophilus influenzae (including beta-lactamase producing strains), Streptococcus pneumoniae and Moraxella catarrhalis. Community acquired pneumonia caused by S. pneumoniae or H. influenza (including beta-lactamase-producing strains). Acute bacterial exacerbation of chronic bronchitis caused by S. pneumoniae, H. influenzae (non-beta-lactamase-producing strains only), or M. catarrhalis. Skin and skin structure infections caused by Staphylococcus aureus, Streptococcus pyogenes. Uncomplicated urinary tract infections caused by E. coli, Klebsiella pneumoniae, Proteus mirabilis or Staphylococcus saprophyticus. Uncomplicated gonorrhea caused by Neisseria gonorrhoeae (including penicillinase-producing strains). Rectal gonococcal infections in women due to Neisseria gonorrhoeae (including penicillinase-producing strains).

Dosage & Administration - Adults and Adolescents (13 years and older) Pharyngitis/tonsillitis: 100 mg 12 hourly, 5 to 10 days Acute maxillary sinusitis: 200 mg 12 hourly, 10 day Community acquired pneumonia: 200 mg 12 hourly, 14 days Acute bacterial exacerbations of chronic bronchitis: 200 mg 12 hourly, 10 days Skin and skin structure: 400 mg 12 hourly, 7 to 14 days Uncomplicated urinary tract infection: 100 mg 12 hourly, 7 days Uncomplicated gonorrhea: single dose of 200 mg Rectal gonococcal infections in women: single dose of 200 mg Infants and Pediatric Patients (2 months to 12 years) Acute otitis media: 5 mg/kg body weight 12 hourly, 5 days Pharyngitis /tonsillitis: 5 mg/kg body weight 12 hourly, 5 to 10 days Acute maxillary sinusitis: 5 mg/kg body weight 12 hourly, 10 days

Side Effects - Cefpodoxime has very few side effects. Possible side effects include gastrointestinal disorders (such as- diarrhea, nausea, vomiting and abdominal pain), rash, urticaria and itching.

Contraindications - Cefpodoxime is contraindicated in patients with known allergy to cephalosporins.

Others - Pregnancy & Lactation US FDA pregnancy category of Cefpodoxime is B. There is, however, no adequate and well-controlled study in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Cefpodoxime have been shown to be excreted in human milk. So, caution should be exercised when Cefpodoxime is administered to a nursing woman. Precautions & Warnings In patients with transient or persistent reduction in urinary output due to renal insufficiency, the total daily dose of Cefpodoxime should be reduced. Cefpodoxime should be administered with caution to patients receiving concurrent treatment with potent diuretics. As with other antibiotics, prolonged use of Cefpodoxime may result in overgrowth of non-susceptible organisms. Use in Special Populations Patients with severe renal impairment (creatinin clearance <30 ml/min) the dosing intervals should be increased to 24 hourly. The dosage adjustment is not require in cases of hepatic impairment. Reconstitution Step 1: Shake the bottle well to loosen the powder. Step 2: Add boiled and cooled water in the bottle. Step 3: Shake until powder is completely mixed with water. Storage Conditions Keep in a dry place away from light and heat. Keep out of the reach of children.