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Indications - Citicoline Sodium is indicated in- Cerebrovascular disease e.g. ischemia due to stroke, where Citicoline accelerates the recovery of consciousness & overcoming motor deficit. Treatment within the first 24 hours after onset in patients with moderate to severe stroke increases the probability of complete recovery in 3 months. Cerebral insufficiency (e.g. dizziness, memory loss, poor concentration & disorientation) due to head trauma or brain injury. Cognitive dysfunction due to degenerative disease (Alzheimer's disease) Parkinson's disease: Citicoline has been shown to be effective as co-therapy for Parkinson's disease.

Dosage & Administration - Oral: Immediate treatment of stroke due to a clot (ischemic stroke): 500-2000 mg of Citicoline per day, start within 24 hours of stroke. For decline in thinking skills due to stroke: 1000-2000 mg of Citicoline per day. Chronic cerebrovascular disease: 1000 mg daily in divided dose with or between meals for ongoing disease of the blood vessels that serve the brain. Injection: 1 to 2 injections daily. Adjust dosage according to the severity. Can be administered through intramuscular (IM), or intravenous (IV) [ 3 to 5 minutes] route.

Side Effects - Occasionally Citicoline may exert stimulating action of the parasympathetic system as well as a fleeting & discrete hypotensive effect.

Contraindications - Patients with hypertonic of the parasympathetic nervous system.

Others - Pregnancy & Lactation There are no adequate & well controlled studies of Citicoline during pregnancy & lactation. Citicoline should be used during pregnancy & lactation only if the potential benefits justify the potential risks.