Indications - Palonosetron indicated in- Acute and delayed nausea and vomiting Uncontrolled nausea and vomiting Chemotherapy-induced nausea and vomiting (CINV): Acute CINV resulting in on the day of treatment with certain types of chemotherapy Delayed CINV resulting in on days later with certain types of chemotherapy Radiotherapy-induced nausea and vomiting (RINV) Post-operative & Post-discharge nausea and vomiting (PONV & PDNV).
Dosage & Administration - Usual dosage: Adult tablet dosage: 0.5 mg daily. Adult IV dosage: A single IV dose of 0.075 mg should be administered over 10 seconds. Chemotherapy-induced nausea and vomiting: Adult tablet dosage: 0.5 mg administered approximately 1 hour prior to the start of chemotherapy. Adult IV dosage: A single IV dose of 0.25 mg should be administered over 30 seconds approximately 30 minutes before the start of chemotherapy. Radiotherapy-induced nausea and vomiting: A single IV dose of 0.25 mg should be administered over 30 seconds approximately 30 minutes before each week of radiation fraction. Post-operative nausea and vomiting: A single IV dose of 0.075 mg should be administered over 10 seconds immediately before induction of anesthesia. Children dosage: (1 month to 17 years): A single IV dose at 20 mcg/kg body weight. Which maximum dose is 1.5 mg.
Side Effects - The most common adverse reactions are headaches and constipation.
Contraindications - Palonosetron is contraindicated in patients known to have hypersensitivity to the drug or any of its components.
Others - Pregnancy & Lactation Pregnancy category 'B'. It is not known whether Palonosetron is excreted in breast milk.
Tablet Paloset 0.5 mg
- Brand Name - Paloset Tablet
- Generic Name - Palonosetron
- Doges From - Tablet
- Strength - 0.5 mg
- Pack Size - 20s
- Manufacture - Square Pharmaceutical Ltd.
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