Indications - Prochlorperazine Maleate is indicated- To control severe nausea and vomiting caused by radiation therapy, cancer chemotherapy, surgery, and other conditions. Relieving nausea, vomiting, and attacks of dizziness or spinning sensations (vertigo) associated with Meniere's disease and other inner ear disorders. For the treatment of psychotic illness such as schizophrenia (hallucinations and hostility). Acute mania. For the short-term treatment of generalized non-psychotic anxiety.
Dosage & Administration - Antiemetic- Children (not recommended in children <10 kg or <2 years): 10-14 kg: 2.5 mg every 12-24 hours as needed;maximum: 7.5 mg/day 15-18 kg: 2.5 mg every 8-12 hours as needed;maximum:10 mg/day 19-39 kg: 2.5 mg every 8 hours or 5 mg every 12 hours as needed; maximum: 15 mg/day. Adults: 5-10 mg 3-4 times/day;usual maximum:40 mg/day Antipsychotic- Children (not recommended in children <10 kg or <2 years): 2-12 years: 2.5 mg 2-3 times/day Increase dosage as needed to a maximum daily dose of 20 mg for 2-5 years and 25 mg for 6-12 years Adults: 5-10 mg 3-4 times/day; doses up to 150 mg/day may be required in some patients for treatment of severe disturbances Nonpsychotic anxiety- Adults: Usual dose: 15-20 mg/day in divided doses; do not give doses >20 mg/day or for longer than 12 weeks Elderly: Initial: 2.5-5 mg 1-2 times/day; increase dose at 4 to 7 day intervals by 2.5-5 mg/day; increase dosing intervals (twice daily, thrice daily, etc) as necessary to control response or side effects; maximum daily dose should probably not exceed 75 mg in elderly; gradual increases (titration) may prevent some side effects or decrease their severity. Prochlorperazine may be administered without regard to the meal
Side Effects - Drowsiness; jaw, neck, and back muscle spasms; fine worm-like tongue movements; rhythmic face, mouth, or jaw movements; slow or difficult speech; difficulty swallowing; restlessness and pacing; tremors; shuffling walk; skin rash; yellowing of the skin or eyes.
Contraindications - Hypersensitivity to prochlorperazine or any component of the formulation, severe CNS depression; coma; should not be used in children <2 years of age or <10 kg.
Others - Pregnancy & Lactation No evidence of adverse effects of this drug has been reported during pregnancy & lactation.
Perkinil Injection
- Brand Name - Perkinil Injection
- Generic Name - Prochlorperazine Maleate
- Doges From - Injection
- Strength - 10 mg
- Pack Size - 1s
- Manufacture - Square Pharmaceutical Ltd.
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